Tissue Engineering and Regenerative Medicine Essay

Tissue Engineering and Regenerative Medicine - Essay Example Even in those cases where patients have been able to afford such transplants, other problems such as organ rejection and incompatibility have deprived them of their precious lives. The gravity of this situation has led to unrelenting research on stem cells, tissue engineering, and regenerative medicine, which are promising and hopeful alternatives to organ transplants. By 2009, in the United States, about 50 million people had survived because of some or the other form of â€Å"artificial organ therapy† (Khademhosseini, Vacanti and Langer, 2009). This gives a clear indication that artificial organs are the hope of the future. This research proposal aims at providing a brief yet objective overview of how an organ can be fabricated by starting with single cells and proceeding to tissue replacement. The proposal is intended to explain how vital organs can be fabricated through bioengineering. The solutions for problems that are usually encountered during fabrication of living org ans are also dealt with. Important challenges include optimization of the decellularization process for the preservation of vascular architecture and for limiting immunogenicity. Overall, this proposal gives a precis on solving cardiovascular diseases by stem cells, tissue engineering and regenerative medicine. Approach to organ fabrication 1. Procurement of stem cells The first step would be to procure embryonic stem cells that would act as progenitors for the cardiac cells. With the help of embryonic stem cells, it is possible to generate both mature cardiocytes as well as the vasculature (Ott et al, 2007). The most appropriate conditions for the growth of these stem cells will be identified and these will be allowed to grow, mature and differentiate before being seeded on a protein matrix for tissue formation. 2. Identification of suitable decellularization procedure for obtaining protein matrix The protein matrix for the generation of tissue and vasculature will be obtained from dead hearts procured from appropriate facilities. Using suitable detergents and chemical treatments, the organs will be decellularized to reveal the protein matrix. Various techniques will be tested before arriving at the most appropriate decellularization agent. 3. Seeding of the protein matrix with progenitor cells The protein matrix will then be seeded with the cardiocytes so that they can naturally develop into tissues and vasculature of a natural heart. Because of the provision of a natural protein matrix and scaffold material derived from a real heart, it will be easier for the cardiocytes to grow three-dimensionally through a natural mechanism. 4. Testing the functionality of the artificially produced organ The functionality of the manufactured heart will be tested and monitored for normalcy of pulse rate and other vital parameters. 5. Animal studies The artificially produced hearts will be transplanted into adult mice and will be tested for development of immunogenicity and health parameters. Possible Problems during Fabrication A major problem during fabrication of an artificial organic heart would be to achieve appropriate tissue vascularization having the vascular structure of a natural

Capstone Project Essay Example for Free

Capstone Project Essay 1.0 Background of the Study Picardal Institute of Science and Technology (PIST) is an institution founded last July 12, 2008 and was located at the 2nd floor of Michaella’s Plaza, Andres Bonifacio Avenue, National Highway, Tibanga, Iligan City, province of Lanao del Norte, Philippines. This institution offers different courses under Commission on Higher Education (CHED) and Technical Education and Skills Development Authority (TESDA) like Bachelor of Science in Information Technology, Associate in Computer Technology, Two Year Graduate in Midwifery Program, Computer Hardware Servicing NC II, Food and Beverage Services NC II, Housekeeping NC II, Shielded Metal Arc Welding NC I and II, Gas Tungsten Arc Welding NC II, Bookkeeping NC III and Programming NC IV. They also offers short courses like Computer Literacy, PC Repair Basic and Advanced AutoCAD, Web Development, WordPress, Photoshop, English Proficiency, Welding Enhancement and Pipefitting. Since from its founding year, PIST in its 6th year in service of providing quality education to its students, they faced so many circumstances and one of it, is the problem in Cashier Department. As of today, the Cashier tends to do her job manually with so many paper works to be done, and so we, the researchers propose a computerized system. This Cashiering System will provide a computerized storing of student’s data, the enrolment assessment of the enrollee with the amount they need to pay during the training and with the entire breakdown. This system will also help the cashier into less paper works and less time to consume in inputting the student information; it can also generate cash flow report, list of student in every semester and daily reports of income. By using this system the cashier will be able to back-up her files, store information of student’s in database and restrict the unauthorized personnel to access this information. The cashier is not the only one who could benefit to this project but also the entire school along with the students, where they could be rest assured  that the Cashier Department will give them real status when it comes to their financial standing. 1.1 Conceptual Framework Through the given input from the student that is the Student’s Personal Information, course and subject load that will be the process and save into the database where we can add, edit, delete and save the student’s number of units as well as their payments and we will be able to assume that through this information we could come up to the expected output that is the summary of student accounts, inquiry of accounts, billing statement and assessment of fees. 1.2 Statement of the Problem This study aims to provide a computerized system that where specifically seek an answer to the following problems. 1. Many paper works. 2. No cashiering system yet. 3. No back-ups and easy to copy, edit and/or delete files without authorization. 4. Manual billing statement. 5. Transactions lack of security. 6. Could be used by unauthorized personnel. 7. Uneasy to search. 8. Summarizing data and writing reports takes a lot of time. 9. Data Duplication. 1.3 Objectives After identifying the problems we came up to these following objectives. 1. To lessen paper works to Cashier Department. 2. To provide a cashiering system. 3. To provide a proper storage with back-up features. 4. To generate a computerized billing statement. 5. To make a tangible system with full security. 6. To provide a system that restrict unauthorized user. 7. To provide a more easy way to search information inside the system. 8. To generate an automated summaries of every transactions. 9. To avoid redundancies of data in the database. 1.4 Significance of the Study This study was made to find out that the use of cashier system will lessen the time for the transaction of billing statements and payment. Also in using this system it can recognize the person involve in this study. This study will benefit the following person: Cashier of Picardal Institute of Science and Technology – it can help them to lessen their tasks in preparing of summary of billing statements. Students – it will provide them an easy way to pay their bills and they will benefit the accurate status of their tuition. To provide good services to students. To the Future Researchers – it can help them as a guide to enhance more from their future thesis. 1.5 Scope and Limitation 1.5.1 Scope The scope of this study focuses only on receiving payments from and process charges of students and also on tracking deposits and payments against student accounts. 1.5.2 Limitation The study is based on the PIST’s System flow and policies in cashiering, thus its capability is according to PIST’s needs only. Definition of Terms Assessment – refers to the total amount of which the enrollee enrolled in that particular academic and/or school year. It is where the student identifies the breakdown of their tuition per academic and/or school year. Billing Statement – it is a monthly or per examination summary of the current and/ or balances of the student’s tuition in that academic and/or school year. Breakdown – is the way that where the student able to see where all of his/her payments go. Cashier – it is a person who works at a store or other business who takes money, makes change, issues receipts and otherwise helps to facilitate customer transactions. Cashiering System – it is a System to receive payments from and process charges for students, employees, and the general public. Cashier Department – is responsible for receiving  and distributing funds, as well as maintaining records. The cashier’s department enables to keep records of dividends and other payouts and receiving payments from the students and /or clients. Computerized System – A computerized system is a computer system with a purpose. When we talk about a computer system, we are simply referring to the hardware and software that comprise the computer system. But when we talk about a computerized system, we are referring to a function (process or operation) integrated with a computer system and performed by trained people. Database A database is an organized collection of data. The data are typically organized to model relevant aspects of reality in a way that supports processes requiring this information. Student – is a learner, or someone who attends an educational institution. Is used for anyone who is learning, including mid-career adults who are taking vocational education or returning to university. CHAPTER 2 REVIEW OF RELATED LITERATURE AND STUDIES This chapter presents a review of related literature and studies gathered from different sources to support the findings and results of the study. 2.0 Related Literature Most institutions and establishments that we visit are using computerized systems to easily cater the needs of the customers or clients. It will also provide a better service to its clientele as well. The system will properly accommodate the needs of the students and the parents in taking the statement of accounts. It will provide an accurate, fast and smart statement of accounts to students that are up-dated for the school administrator and the students. It will also provide students to view their own statement of accounts. When having a computerized system we will be able to have an advantages and disadvantages. The advantages of having a computerized system are: Saving Time One important advantage offered by computerized accounting is it can save time for small business owners, who often must wear many hats. Calculations for functions like  payroll and billing can be performed quickly and efficiently by accounting software programs designed for small businesses. You can also access accounting records quickly without having to sift through stacks of paper. This can allow you to spend more time working with clients or performing marketing functions to help your business grow. Reduced Errors Manual number crunching presents the possibility of human error, which can be costly to a small business owner who may be in a hurry to complete an accounting task. Computerized accounting programs can reduce calculation errors that can result in inaccurate inventory counts, billing for too large or small of an amount or incorrect sales receipt totals. Having accurate accounting information can also help you avoid tax errors that could lead to problems with the Internal Revenue Service. Disadvantages: Dependence on Machinery On the downside, as with all machines, computers can fail from time to time, and a computer crash could leave you unable to perform accounting tasks and even result in the loss of information if files are not backed up properly. If you and/or your staff has little accounting knowledge and relies heavily on your computerized accounting program to do all the work, you may be at a loss as to what to do when your system or computer fails. Security breaches can also result in lost or stolen data. Expense Another disadvantage is that if youre converting from a manual to mechanized accounting system, youll need to bear the expense of software and possibly even new computers. Training on how to use a computerized system can result in lost productivity due to the associated downtime and learning curve. As time goes by, youll likely need to spend money on software upgrades as new versions become available. When your computers malfunction, youll need to pay for potentially costly repairs or replacements. Fewer errors mean fewer headaches there are countless ways in which errors can creep into your transactions. The more data entry required, the greater the chances for error. So a cashiering system which is able to supply the required information on the cashier’s behalf, while minimizing data entry, is highly desirable. Put another way, the more  automation applied to the process, the better. Provide outstanding service – it will reduce excessive waiting in line, eliminate delays in restoring the paid-up status of a student account, avoid egregious errors such as posting payments to the bank, provide for rapid production of duplicate receipts, cancel non-paying students more promptly to accommodate returning students, accepts payments even when the student system is down and automatically release the appropriate students holds when an account is made current. Note: Author year 2.1 Related Studies According to the research we made, there are other institutions here in Iligan City that uses computerized systems for Cashier Department that would assessed the students in a more easy and handful way. With this computerized system, it lessens the time consumed in accommodating all the students who will made transactions in the cashier department. Note: Author year Chapter III RESEARCH DESIGN AND METHODOLOGY The topics are given a deeper explanation in this chapter and the researchers will present the study. It consist of the research method, research instrument, interview, questionnaire, construction, validation, survey, administration and retrieval, research locale, population and sampling techniques, data gathering procedure, project design, project development, testing and operating procedures. 3.0 Project Design Through observation and interview we come up to these designs and coding.

Report On Westside Gym :: Papers

Report On Westside Gym Introduction This report will be research and development of a gym called â€Å"Westside Health & Fitness Club†. I will talk about the location of the gym, price per customer, offers, new ways to improve the gym, and research into what the customer wants. This report aims to use research and development to create innovative ideas that will set this gym apart from others in the area. Findings With regards to the location of the gym, the evidence suggests that the location is well placed, due to the easy accessibility of the facilities. It is also located next to a supermarket, so can be seen by many shoppers. Place is an essential tool of the marketing mix and if achieved a business can do extremely well for itself. Price is also an essential tool of the marketing mix. A survey showed that 81% thought that the price of the gym was fair for the quality of service that is received by the customers. The other 19% believed the price was too high but were willing to pay for the facilities. A good pricing strategy is a must for a business to succeed, too high and customers will go elsewhere for the service. Too low and the business may not make enough profit to succeed in the long term. Cost of Gym Membership: Student Rate Adult Rate Joining Fee  £40.00  £50.00 Monthly payment  £28.95  £38.95 Pay As You Go  £2.50  £5.

Importance of Securing Items

It would be nice if we were able to wake up, get dressed, and lay out any additional clothes, or uniforms we may need later on in the day. Then go to eat breakfast at a local favorite restaurant; getting in and out of your vehicle quickly without care or worry. It would be nice to chat and trade info with your friends and family, or enquire help with someone different on-line. To be able to come back home after a long day of work, and leave the outside world to itself, would be great! However, the reality of it all is that doing so in this world, is not only dangerous, but also potentially deadly. For us to be able to function in today’s society requires security. And this security is needed in almost every aspect of life; no matter how large or small it may be. Yes, everyone can agree that a vehicle needs to be secured. Without security, criminals are able to climb in, start it up, and drive off. You have just lost your primary form of transportation. That leads to delays in work, or even losing a job. Then trying to get a job would be difficult without a vehicle, making life more and more trying. In today’s news, as well as ads, we are informed of the importance of security when it comes to one’s home. Criminals and burglars, target locations with no or very little security. Large valuable items are easily obtained through this. Even one’s life is in potential danger without home security. One of the most important things that need security, whether you are single or a family, is as simple as a desk or wall locker. Almost everything we do each day can be found in one. We tend to put car keys, and house keys in a desk or locker. We also tend to keep important paper or receipts from wherever we went or did through the day. Or we may have small items like jewelry, and cash stored away. Without security measures in place, these items would be directly obtainable to anyone. Not only from those that want to take things from you. Not only from those that would take and use your things against you, like your bank info, your social security number; to name a few. But also those near to you that you love. A Child can enter an unsecured cabinet and get hands on poisonous cleaning supplies, or medications; or even a handgun that may have been meant for protection. It would nearly, if not be the worst to ever happen to lose a child, or other family member, because a locker or desk was unsecured. So it is very important to be ever vigilant in ensuring that your things, especially your wall locker is secured at all times. Start practicing today, and every day. Then you can have one of those days that will be nice to wake up to safe, and sound.

Edwards’ Sermon “Sinners in the Hands of an Angry God” Essay

When first reading Jonathan Edwards’ sermon, â€Å"Sinners in the Hands of an Angry God,† shocked readers how it started right in about the wrath of God and Hell. His diction and images create a tone of alarming immediacy – act now for your own good. â€Å"The bow of God’s wrath is bent†, the arrow ready to pierce the heart of a sinner. Edwards uses this frightening image to compare the power of God to the people. His point is that he wants to persuade sinners to repent. Edwards seems to feel a harsh tone is needed in this to get the point across that they need God to lead them out of the dreadful pit. Edwards’ word choices present a contradiction, saying that people who have a relationship with God can still go to Hell because there is only God’s hand holding us up from Hell. The word â€Å"obligation† implies that the arrow could pierce a sinner’s heart right now, during his sermon. Also, â€Å"everlasting destructionà ¢â‚¬  has a big impact, telling people that they can have life if they follow God, or be swallowed up by Hell. Edwards is didactic and harsh with the information he tries to convey to the congregation, scaring them he hopes, into salvation. He uses these tools to help the tone on the importance of knowing God and how people’s lives can be changed. He does this out of love, trying to tell them how it really is and wanting them to choose the right way. This frightening, bullying tone is a far cry from the 21st century sermons which emphasize God’s love for mankind as in the well known verse John 3:16.